目的 通过随机对照试验探究药师在获得性免疫缺陷综合征患者药物治疗管理上的作用与价值,为国内开展艾滋病药物治疗管理服务提供参考依据。方法 2019年5~11月在某医院感染中心门诊处,招募用药依从性差的艾滋病患者。将符合入选标准的84名患者随机分配到干预组和对照组,每组各42名患者。对照组患者仅接受常规诊疗服务,干预组除常规诊疗服务外,接受由药师提供的药物治疗管理服务,干预时间为6个月。观察指标为:两组患者入组6个月后用药依从性评分、生活质量评分及CD4+T淋巴细胞计数变化情况。结果 经过6个月的研究,干预组依从性改善率明显高于对照组(86.1% vs 62.8%,P=0.006),且干预组的用药依从性评分高于对照组(6.78±1.17 vs 5.91±1.27,P=0.004)。另外,干预组的生活质量评分高于对照组(0.853±0.012 vs 0.816±0.013,P=0.045),但两组患者的CD4+T淋巴细胞计数差异无统计学意义[(278.9±75.4)vs (261.48±108.1),P=0.436]。结论 药师主导的药物治疗管理服务能够有效提高艾滋病患者的用药依从性和生活质量,该服务在艾滋病患者的实践中具有可行性,值得深入探索。
Abstract
OBJECTIVE To explore the role and value of pharmacists in the management of AIDS patients through randomized controlled trials, and provide reference for the development of medication therapy management service for AIDS patients in China. METHODS From May 2019 to November 2019, AIDS patients with poor medication compliance were recruited in the outpatient department of Infection Center in one hospital. Eighty-four patients who met the inclusion criteria were randomly assigned to intervention group and control group, 42 patients in each group. The patients in the control group only received routine diagnosis and treatment services. In addition to routine diagnosis and treatment services, the intervention group received medication therapy management services provided by pharmacists for an intervention period of 6 months. Observation indicators were changes in medication compliance scores, quality of life scores, and CD4+T lymphocyte counts at 6 months after enrollment. RESULTS After the 6-month study, the compliance improvement rate of the intervention group was significantly higher than that of the control group (86.1% vs 62.8%, P=0.006), and the medication compliance score of the intervention group was higher than that of the control group (6.78±1.17 vs 5.91 ±1.27, P=0.004). In addition, the quality of life score of the intervention group was higher than that of the control group (0.853±0.012 vs 0.816±0.013, P=0.045), but there was no statistically significant difference in CD4+T lymphocyte count between the two groups (278.9±75.4 vs 261.48±108.1, P=0.436). CONCLUSION The pharmacist-led medication therapy management service can effectively improve the medication compliance and quality of life of AIDS patients. This service is feasible in the practice of AIDS patients and is worth exploring in depth.
关键词
药物治疗管理 /
获得性免疫缺陷综合征 /
用药依从性 /
生活质量 /
随机对照研究
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Key words
Medication therapy management services /
acquired immunodeficiency syndrome /
medication adherence /
quality of life randomized controlled trial
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中图分类号：
R969.3
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